In the United States, around 30,000 deaths per year have been reported ( Lessa et al., 2015). 418 (26%) of the patients registered in Germany in 2020 did not survive their illness ( Robert-Koch-Institute, 2020). difficile ribotype in the State of Lower Saxony ( Seugendo et al., 2018). difficile, large variation of 0.6 to 37.4% has also been found in Germany for the prevalence of ribotype 027 ( Marujo and Arvand, 2020), with a 10.3% prevalence rate of this C. Like has been described for the general prevalence of C. It is assumed that there are at least 1,500 severe CDIs in Germany per year, with regional incidences varying between 0.2 (State of Saarland) and 6.6 diseases/100,000 inhabitants (State of Saxony-Anhalt). The frequency of Clostridioides difficile infections (CDIs) has been increasing worldwide for more than 15 years ( Rupnik et al., 2009). difficile or only the toxins are detectable in the stool and there are no other explanations for the arthritis and diarrhea. difficile-associated reactive arthritis (CDARA) is characterized by the fact that patients suffer from diarrhea or colitis after taking antibiotics, toxigenic C. difficile can also lead to reactive arthritis. The case history together with the review of 45 other cases described so far shows that C. The further investigation showed that the patient - in contrast to his partner - was HLA-B27 positive and had strong antibody levels against C. difficile ribotype 027, but did not develop reactive arthritis. His female partner also became infected with C. difficile of the hypervirulent ribotype 027. We report on a 69-years-old man who developed reactive arthritis of his right knee joint one week after antibiotic-associated diarrhea with evidence of C. However, the fact that Clostridioides difficile infection (CDI) can also lead to this complication is largely unknown. With an annual incidence of 250-300 per 100,000 inhabitants, reactive arthritis is not uncommon. Martini Hospital, Clinic for Internal Medicine and Gastroenterology, Duderstadt, Germany 2Department of Transfusion Medicine, University Medical Center Göttingen, Göttingen, Germany.1Institute for Medical Microbiology and Virology, University Medical Center Göttingen, Göttingen, Germany.Ortrud Zimmermann 1 Heinrich Köchel 1 Wolfgang Bohne 1 Beatrix Pollok-Kopp 2 Peter Passenberg 3 Uwe Groß 1*
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